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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: colony-stimulating factor-primed donor leukocyte infusion (chemo-DLI), was investigated in patients with high-risk myelodysplasticsyndrome (MDS) who were MRD-positive after allogeneic hematopoietic stem cell transplantation (allo-HSCT

Keywords: donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 238-249 doi: 10.1007/s11684-017-0599-3

Abstract: The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) ( =24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.

Keywords: interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 288-303 doi: 10.1007/s11684-015-0412-0

Abstract: signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplasticsyndrome, and acute myeloid leukemia.

Keywords: TLR     MyD88     hematopoiesis     bone marrow failure     leukemia     myelodysplastic syndrome    

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 651-658 doi: 10.1007/s11684-021-0859-0

Abstract: To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifestedcomplaint of throat discomfort, absence of chest pain at onset, and an ultimate diagnosis of acute coronary syndromedyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndromeThroat discomfort can be the principal manifestation of acute coronary syndrome.throat symptoms, chest tightness, perspiring, and dyspnea were important indicators of acute coronary syndrome

Keywords: acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic    

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 419-426 doi: 10.1007/s11684-014-0383-6

Abstract: of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndromereview, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndromeIn conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital

Keywords: sinus of Valsalva aneurysms     Marfan syndrome     aortic dissection    

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 224-228 doi: 10.1007/s11684-017-0538-3

Abstract:

Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a

Keywords: bronchiolitis obliterans syndrome (BOS)     hematopoietic stem cell transplantation (HSCT)     lung transplantation    

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 333-339 doi: 10.1007/s11684-017-0564-1

Abstract:

Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy

Keywords: nephrotic syndrome     focal segmental glomerulosclerosis     genetic    

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

Wei Wang,Fengyi Yuan,Dan Xu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 380-383 doi: 10.1007/s11684-015-0407-x

Abstract:

Cushing’s syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal

Keywords: Cushing’s syndrome     pregnancy     adrenocortical adenoma    

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 177-180 doi: 10.1007/s11684-007-0033-3

Abstract: The aim of the present research is to study the mechanism of cervical nerve compression syndrome of themedicine and celecoxib (COX)-2 inhibitor were performed in 20 patients with cervical nerve compression syndromeFifteen cases with cervical nerve compression syndrome of the external intervertebral foramen were healedThe etiology of cervical nerve compression syndrome of the external intervertebral foramen lies in theDiagnostic treatment was propitious to differentiate cervical nerve compression syndrome of the external

Keywords: satisfactory     COX     minimus     operation     compression syndrome    

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 293-296 doi: 10.1007/s11684-017-0516-9

Abstract: The patient presented with hypertension, chronic Guillain-Barre syndrome, and sick sinus syndrome.the diagnosis of familial amyloid cardiomyopathy, which was misdiagnosed as chronic Guillain-Barre syndrome

Keywords: transthyretin (TTR) cardiac amyloidosis     sick sinus syndrome     chronic Guillain-Barre syndrome    

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

Jaffar A. Al-Tawfiq,Ali S. Omrani,Ziad A. Memish

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 111-119 doi: 10.1007/s11684-016-0446-y

Abstract:

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memoriesof the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002.

Keywords: coronavirus     MERS     Middle East respiratory syndrome    

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract: Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabeticThe associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem fromHowever, whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetesTheoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complicationssummarize these pieces of available information, possible mechanisms by which Zn prevents the metabolic syndrome

Keywords: zinc     zinc transporters     metallothionein     diabetes     diabetic complications     insulin resistance     antioxidant    

Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 45-48 doi: 10.1007/s11684-009-0019-4

Abstract: This study was aimed to explore the anterior cervical surgery methods to treat central cord syndrome

Keywords: central cord syndrome     decompression     surgical     titanium mesh    

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

Frontiers of Medicine doi: 10.1007/s11684-023-1011-0

Abstract: nirmatrelvir/ritonavir (Paxlovid) therapy for hemodialysis-dependent patients with severe acute respiratory syndrome

Keywords: Paxlovid     hemodialysis     SARS-CoV-2     viral load     chest CT scan    

discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader–Willi syndrome

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 946-956 doi: 10.1007/s11684-022-0962-x

Abstract: Prader–Willi syndrome (PWS) is a rare congenital disease with genetic alterations in chromosome 15.

Keywords: Prader–Willi syndrome     early diagnosis     erythrocyte deformation     membrane skeleton     membrane lipid    

Title Author Date Type Operation

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Journal Article

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Journal Article

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Journal Article

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Journal Article

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang

Journal Article

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

Wei Wang,Fengyi Yuan,Dan Xu

Journal Article

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

Journal Article

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Journal Article

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

Jaffar A. Al-Tawfiq,Ali S. Omrani,Ziad A. Memish

Journal Article

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Journal Article

Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

Journal Article

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus

Journal Article

discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader–Willi syndrome

Journal Article